Mouse anti Human CD41:RPE,clone PM6/248
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Mouse anti Human CD41:RPE,clon

e PM6/248
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  • 询价
  • BIO-RAD已认证
  • MCA467PE
  • 2025年10月17日
  • F
  • Human
  • 详细信息
  • 文献和实验
  • 技术资料
  • 免疫原

    Human platelet plasma membranes.

  • 亚型

    IgG1

  • 形态

    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized

  • 克隆性

    Monoclonal Antibody

  • 标记物

    RPE

  • 适应物种

    Human

  • 保质期

    自发货之日起 12 个月

  • 目录编号

    PM6/248

  • 供应商

    伯乐生命医学产品(上海)有限公司

  • 应用范围

    F

  • 抗体名

    CD41 antibody | PM6/248

  • 规格

    100 Tests

Mouse anti Human CD41 antibody, clone PM6/248 recognizes the human CD41 cell surface antigen, a ~140 kDa glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.

It has not been established if clone PM6/248 recognizes free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.


储存信息

This product is shipped at ambient temperature.
Prior to reconstitution store at +4oC. Following reconstitution store at +4oC.

DO NOT FREEZE.

This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.


应用

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 100ul whole blood.


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图标文献和实验
该产品被引用文献

References for CD41 antibody

  1. Hornby, E.J. et al. (1991) Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa.
    Br J Haematol. 79 (2): 277-85.
  2. Michelson, A.D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons.
    Leucocyte Typing V. Oxford University Press p 1230-1231.
  3. Zahler, S. et al. (1999) Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass.
    Cardiovasc Res. 41: 722-30.
  4. Massoudy, P. et al. (2001) Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass.
    Chest. 119: 31-6.
  5. Wang, J.S. et al. (2005) Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men.
    Arterioscler Thromb Vasc Biol. 25: 454-60.
  6. Kahng, J. et al. (2008) Quantitative comparisons of antibody-binding sites of platelet glycoprotein IIb/IIIa in aplastic anemia and idiopathic thrombocytopenic purpura.
    Ann Clin Lab Sci. 38: 6-11.
  7. Chae, H. et al. (2009) EDTA Inhibits the Binding of Clone 96.2C1, an Anti-CD41a Monoclonal Antibody, to the Platelets and Addition of Heparin and CaCl2 to the Antibody Neutralizes the EDTA-induced Inhibitory Effect
    Korean J Hematol 44: 42 - 6.
  8. Maloney, S.F. ety al. (2010) P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
    Integr Biol (Camb). 2: 183-92.
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Mouse anti Human CD41:RPE,clone PM6/248
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