- 询价
- BIO-RAD
- MCA5921
- 2025年10月17日
- P
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthetic peptide, sequence CTQPTSGQERPPSRVAS.
- 亚型：
IgG2a
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
sstr3
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
P
- 浓度：
IgG concentration 1mg/ml
- 抗体名：
Somatostatin Receptor 3 antibody | sstr3
- 规格：
0.2 mg
Mouse anti Human Somatostatin Receptor 3 antibody, clone sstr3 recognizes human somatostatin receptor 3. Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.
The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.
Mouse anti Human Somatostatin Receptor 3 antibody, clone sstr3 does not recognize any of the other SSTR subtypes.
The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.
Mouse anti Human Somatostatin Receptor 3 antibody, clone sstr3 does not recognize any of the other SSTR subtypes.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | ✓ | ||
| Western Blotting | × |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human breast cancer
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文献和实验该产品被引用文献
Source Reference
- Schmid, H.A. et al. (2012) Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.
Neuroendocrinology. 95 (3): 232-47.
References for Somatostatin Receptor 3 antibody
- Ozkaya, H.M. et al. (2018) Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1-5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues.
Pituitary. 21 (4): 335-346. - Remes, S.M. et al. (2019) Immunohistochemical Expression of Somatostatin Receptor Subtypes in a Panel of Neuroendocrine Neoplasias.
J Histochem Cytochem. 67 (10): 735-43.
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文献支持
Mouse anti Human Somatostatin Receptor 3，clone sstr3
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