- 询价
- BIO-RAD
- HCA427
- 2025年10月17日
- E
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- 详细信息
- 技术资料
- 免疫原：
Benralizumab
- 亚型：
IgG1
- 形态：
Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD59975ia
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
Benralizumab antibody | AbD59975ia
- 规格：
0.1 mg
Human Anti-Benralizumab Antibody, clone AbD59975ia is a paratope specific, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug benralizumab. It does not recognize the drug target, human interleukin 5 receptor α (IL5Rα), nor benralizumab in complex with IL5Rα. This antibody can be used to measure free benralizumab levels in serum from patients.
HCA427 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 4nM and is one of the three antibodies offered for ADA assays. Antibody HCA426 has an affinity of 0.2nM and HCA428 has an affinity of 6nM.
Benralizumab (trade name Fasenra) is a humanized monoclonal antibody of the IgG1/kappa isotype that binds with high affinity to a conformationally distinct epitope within domain 1 of the α-chain of IL-5R, and thus inhibits proliferation of IL-5-dependent cell lines, and otherwise blocks signaling through the IL-5 receptor. Benralizumab is indicated as a maintenance treatment for severe asthma and an eosinophilic phenotype.
View a summary of all anti-benralizumab antibodies
HCA427 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 4nM and is one of the three antibodies offered for ADA assays. Antibody HCA426 has an affinity of 0.2nM and HCA428 has an affinity of 6nM.
Benralizumab (trade name Fasenra) is a humanized monoclonal antibody of the IgG1/kappa isotype that binds with high affinity to a conformationally distinct epitope within domain 1 of the α-chain of IL-5R, and thus inhibits proliferation of IL-5-dependent cell lines, and otherwise blocks signaling through the IL-5 receptor. Benralizumab is indicated as a maintenance treatment for severe asthma and an eosinophilic phenotype.
View a summary of all anti-benralizumab antibodies
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
-
Clone AbD59975ia can be used in indirect ELISA to detect benralizumab. It can also be used as a surrogate positive control or a calibrator in an anti-drug antibody (ADA) assay, together with HCA426 and HCA428.
Protocol: ADA bridging ELISA
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Human anti Benralizumab，clone AbD59975ia
询价
