- 询价
- BIO-RAD
- HCA414
- 2025年10月17日
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- 详细信息
- 技术资料
- 免疫原：
Risankizumab
- 亚型：
IgG1
- 形态：
Human IgG1 antibody (kappa light chain) selected from the HuCAL phage display library and expressed in a human cell line. This product is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD59012ia
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
Risankizumab antibody | AbD59012ia
- 规格：
0.1 mg
Human Anti-Risankizumab Antibody, clone AbD59012ia is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug risankizumab, and its biosimilar products. It does not recognize the drug target, human Interleukin 23 (IL-23), nor risankizumab in complex with IL-23. This antibody can be used to measure free risankizumab levels in serum from patients.
HCA414 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 0.1nM and is one of the three antibodies offered for ADA assays. Antibody HCA415 has an affinity or 5nM and HCA416 has an affinity of 8nM.
Clone AbD59012ia is also available as a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain (TZA058) for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog.
Risankizumab (trade name Skyrizi) is a humanized monoclonal antibody of the IgG1/kappa isotype that suppresses the inflammatory effects of interleukin-23 by selectively targeting its unique p19 subunit, subsequently inhibiting IL-23 binding to its receptor and the signaling responsible for the release of pro-inflammatory cytokines and chemokines. Risankizumab is indicated as an interleukin-23 antagonist in the treatment of plaque psoriasis, psoriatic arthritis and Crohn's disease in adults.
View a summary of all anti-risankizumab antibodies
HCA414 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 0.1nM and is one of the three antibodies offered for ADA assays. Antibody HCA415 has an affinity or 5nM and HCA416 has an affinity of 8nM.
Clone AbD59012ia is also available as a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain (TZA058) for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog.
Risankizumab (trade name Skyrizi) is a humanized monoclonal antibody of the IgG1/kappa isotype that suppresses the inflammatory effects of interleukin-23 by selectively targeting its unique p19 subunit, subsequently inhibiting IL-23 binding to its receptor and the signaling responsible for the release of pro-inflammatory cytokines and chemokines. Risankizumab is indicated as an interleukin-23 antagonist in the treatment of plaque psoriasis, psoriatic arthritis and Crohn's disease in adults.
View a summary of all anti-risankizumab antibodies
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
-
Clone AbD59012ia can be used in indirect ELISA to detect risankizumab. It can also be used as a surrogate positive control or a calibrator in an anti-drug antibody (ADA) assay, together with HCA415 and HCA416.
Protocol: ADA bridging ELISA
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Human anti Risankizumab，clone AbD59012ia
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