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- BIO-RAD
- TZA0112
- 2025年10月17日
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- 详细信息
- 技术资料
- 免疫原：
Canakinumab/IL-1 beta complex
- 亚型：
Fab antibody
- 形态：
A monovalent human recombinant Fab (lambda light chain) selected from the HuCAL® phage display library, expressed in a proprietary E. coli strain. The antibody is tagged with a DYKDDDDK tag, a SpyTag version 2 (VPTIVMVDAYKRYK) and a His6-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD54142
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
Canakinumab antibody | AbD54142
- 规格：
0.1 mg
Human Anti-Canakinumab (Drug/Target Complex) Antibody, clone AbD54142 specifically recognizes the antibody drug canakinumab when in complex with its target, the human interleukin-1 beta (IL-1β). It does not recognize free canakinumab nor unbound IL-1β.
The monovalent Fab format of this antibody, clone AbD54142ad (TZA0112) is tagged with a SpyTag2 at the C-terminus of the Fab heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour.
This antibody is also available as a bivalent Fab antibody pre-coupled to the HRP-conjugated BiSpyCatcher2 (TZC002P) under product code TZA0112P for direct detection of the Canakinumab/ IL-1β complex in bioanalysis assays.
Clone AbD54142 can be used in pharmacokinetic (PK) antigen capture format assays to measure canakinumab that has been captured via immobilized IL-1β. It is ideal for bioanalytical assays to measure the level of drug or biosimilar in complex with the IL-1β target.
Canakinumab (trade name Ilaris) is a fully humanized monoclonal IgG1/kappa antibody with allotype G1m3. It binds to interleukin-1 beta (IL-1β) to neutralize up-regulated 1β signaling, resulting in suppression of inflammation in patients with disorders of autoimmune origin. Canakinumab is indicated for treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), three rare and serious auto-inflammatory diseases, Still’s disease, and gouty arthritis.
View a summary of all anti-canakinumab antibodies
The monovalent Fab format of this antibody, clone AbD54142ad (TZA0112) is tagged with a SpyTag2 at the C-terminus of the Fab heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour.
This antibody is also available as a bivalent Fab antibody pre-coupled to the HRP-conjugated BiSpyCatcher2 (TZC002P) under product code TZA0112P for direct detection of the Canakinumab/ IL-1β complex in bioanalysis assays.
Clone AbD54142 can be used in pharmacokinetic (PK) antigen capture format assays to measure canakinumab that has been captured via immobilized IL-1β. It is ideal for bioanalytical assays to measure the level of drug or biosimilar in complex with the IL-1β target.
Canakinumab (trade name Ilaris) is a fully humanized monoclonal IgG1/kappa antibody with allotype G1m3. It binds to interleukin-1 beta (IL-1β) to neutralize up-regulated 1β signaling, resulting in suppression of inflammation in patients with disorders of autoimmune origin. Canakinumab is indicated for treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), three rare and serious auto-inflammatory diseases, Still’s disease, and gouty arthritis.
View a summary of all anti-canakinumab antibodies
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols for coupling a Fab antibody with a SpyTag to a SpyCatcher can be found at SpyTag and SpyCatcher Products, and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual
- ELISA
-
Clone AbD54142ad may be used in an indirect ELISA to detect the human IL-1 beta/canakinumab complex or to detect canakinumab bound to immobilized IL-1 beta.
Protocol: PK bridging ELISA
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Human anti Canakinumab (Drug/Target Complex)，clone AbD54142
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