- 询价
- BIO-RAD
- VMA00932
- 2025年10月17日
- WB
- Human
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- 详细信息
- 技术资料
- 免疫原：
E. coli-derived recombinant protein of amino acids 1-230 of human UCHL3
- 亚型：
IgG2b
- 形态：
Purified IgG - Liquid
- 克隆性：
PrecisionAb Monoclonal
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
AB04/3F5
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
WB
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
UCHL3 antibody | AB04/3F5
- 规格：
100 µl
Mouse anti UCHL3 antibody recognizes ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as Ubiquitin thioesterase L3.
Ubiquitin C-terminal hydrolases are deubiquitinating enzymes involved with processing pro-ubiquitin gene products and catalyzing removal of small molecules from ubiquitin (Han et al. 2018). Regulation of the major pathway for repair of DNA double-strand breaks is achieved in part by UCHL3, maintaining genome integrity (Nishi et al. 2018). UCHL3 is phosphorylated and activated by ATM in response to DNA damage (Luo et al. 2016), and plays a role in DNA repair by ubiquitylating TDP1. Disruption of TDP1 can cause neurological disease and resistance to chemotherapy in cancer (Liao et al. 2018). A role of UCHL3 has been suggested in the response to cancer therapy, with high expression rendering breast cancer cells resistant to radiation and chemotherapy, and low expression sensitizing cells to these treatments (Luo et al. 2016).
Ubiquitin C-terminal hydrolases are deubiquitinating enzymes involved with processing pro-ubiquitin gene products and catalyzing removal of small molecules from ubiquitin (Han et al. 2018). Regulation of the major pathway for repair of DNA double-strand breaks is achieved in part by UCHL3, maintaining genome integrity (Nishi et al. 2018). UCHL3 is phosphorylated and activated by ATM in response to DNA damage (Luo et al. 2016), and plays a role in DNA repair by ubiquitylating TDP1. Disruption of TDP1 can cause neurological disease and resistance to chemotherapy in cancer (Liao et al. 2018). A role of UCHL3 has been suggested in the response to cancer therapy, with high expression rendering breast cancer cells resistant to radiation and chemotherapy, and low expression sensitizing cells to these treatments (Luo et al. 2016).
储存信息
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | ✓ | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Learn about how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Mouse anti UCHL3，clone AB04/3F5
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