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- 详细信息
- 技术资料
- 免疫原:
E. coli-derived recombinant protein of amino acids 1-249 of human PSME1
- 亚型:
IgG1
- 形态:
Purified IgG - Liquid
- 克隆性:
PrecisionAb Monoclonal
- 标记物:
Purified
- 适应物种:
Human
- 保质期:
自发货之日起 12 个月
- 目录编号:
AB02/4C4
- 供应商:
伯乐生命医学产品(上海)有限公司
- 应用范围:
IP, WB
- 浓度:
IgG concentration 1.0 mg/ml
- 抗体名:
PSME1 antibody | AB02/4C4
- 规格:
100 µl
Mouse anti PSME1 antibody recognizes proteasome activator complex subunit 1, also known as REG-alpha, IGUP I-5111, and PA28a.
PSME1 encodes a subunit of the proteinase system, required for efficient processing of antigens and for assembly of the immunoproteasome (Vigneron and Van den Eynde 2014). Antigen presenting cells and many other cell types express PSME1 under the control of interferon gamma. PSME1 is involved with immune defense against cancer, by generating tumor antigens presented by MHC class I molecules. High expression of PSME1 is associated with poor metastasis-free survival in patients with soft tissue leiomyosarcoma, and has been suggested as a prognostic biomarker for this cancer type (Lou et al. 2016), and also esophageal squamous cell carcinoma (Zhang et al. 2011) and prostate cancer (Sanchez-Martin et al. 2013).
PSME1 encodes a subunit of the proteinase system, required for efficient processing of antigens and for assembly of the immunoproteasome (Vigneron and Van den Eynde 2014). Antigen presenting cells and many other cell types express PSME1 under the control of interferon gamma. PSME1 is involved with immune defense against cancer, by generating tumor antigens presented by MHC class I molecules. High expression of PSME1 is associated with poor metastasis-free survival in patients with soft tissue leiomyosarcoma, and has been suggested as a prognostic biomarker for this cancer type (Lou et al. 2016), and also esophageal squamous cell carcinoma (Zhang et al. 2011) and prostate cancer (Sanchez-Martin et al. 2013).
储存信息
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation | ✓ | ||
| Western Blotting | ✓ | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Learn about how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Mouse anti PSME1,clone AB02/4C4
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