- 询价
- BIO-RAD
- MCA6411GA
- 2025年10月17日
- IP, WB
- Human
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- 详细信息
- 技术资料
- 免疫原：
E. coli-derived recombinant protein, aa 600-996 of human POLR3A
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
AB01/1E10
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
IP, WB
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
POLR3A antibody | AB01/1E10
- 规格：
0.1 mg
Mouse anti Human POLR3A antibody recognizes POLR3A, otherwise known as DNA-directed RNA polymerase III largest subunit, DNA-directed RNA polymerase III subunit A, RNA polymerase III 155kDa subunit and RNA polymerase III subunit C160.
DNA-directed RNA polymerase is responsible for catalyzing the transcription of DNA into RNA via the four ribonucleoside triphosphates as substrates. It constitutes the largest and catalytic core of RNA polymerase III and transcribes small RNAs such as 5S rRNA and tRNAs; molecules essential for the normal functioning and survival of cells (Dieci et al. 2007). This protein plays a critical role in detecting and controlling infection by intracellular bacteria and DNA viruses. It also acts as a non-self double stranded DNA sensor in the innate immune response. Synthesis of non–self DNA into RNA leads to type I interferon production via the RIG-1 pathway (Chiu et al. 2009). Mutations in the POLR3A gene have been linked to a cluster of inherited neurodegenerative disorders called Hypomyelinating Leukodystrophy (Bernard et al. 2011). Furthermore, studies show the possible connection of the mutated POLR3A gene to autoimmune diseases such as Scleroerma.
Mouse anti Human POLR3A antibody detects a band of 157 kDa.
DNA-directed RNA polymerase is responsible for catalyzing the transcription of DNA into RNA via the four ribonucleoside triphosphates as substrates. It constitutes the largest and catalytic core of RNA polymerase III and transcribes small RNAs such as 5S rRNA and tRNAs; molecules essential for the normal functioning and survival of cells (Dieci et al. 2007). This protein plays a critical role in detecting and controlling infection by intracellular bacteria and DNA viruses. It also acts as a non-self double stranded DNA sensor in the innate immune response. Synthesis of non–self DNA into RNA leads to type I interferon production via the RIG-1 pathway (Chiu et al. 2009). Mutations in the POLR3A gene have been linked to a cluster of inherited neurodegenerative disorders called Hypomyelinating Leukodystrophy (Bernard et al. 2011). Furthermore, studies show the possible connection of the mutated POLR3A gene to autoimmune diseases such as Scleroerma.
Mouse anti Human POLR3A antibody detects a band of 157 kDa.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation | ✓ | ||
| Western Blotting | ✓ | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Learn about how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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技术资料暂无技术资料 索取技术资料
Mouse anti Human POLR3A，clone AB01/1E10
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