- 询价
- BIO-RAD
- MCA216T
- 2025年10月17日
- C *, F
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Human leucocytes from individuals with CML.
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
80H3
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C *, F
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
CD66b antibody | 80H3
- 规格：
20 µg
Mouse anti Human CD66b antibody, clone 80H3 reacts with the CEACAM8 or CGM6 gene product, from the carcinoembryonic gene family. The CEACAM8 gene product is called CD66b, Non-specific cross-reacting antigen NCA-95 or Carcinoembryonic antigen CGM6. CD66b is a 286 amino acid mature ~95-100 kDa GPI anchored molecule with an N-terminal 34 amino acid signal peptide and a 29 amino acid C-terminal propeptide, shed in the mature form. CD66b is expressed strongly by mature granulocytes and metamyelocytes, and weakly by bone marrow myelocytes. CD66b is not expressed by peripheral blood monocytes or lymphocytes.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | 1/50 | 1/100 |
| Immunohistology - Frozen 1 | ✓ | 1/25 | 1/100 |
| Immunohistology - Paraffin | × |
- 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of * fixation for frozen sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 5 x 105 cells or 100ul whole blood.
- Histology Positive Control Tissue
- Bone Marrow
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文献和实验该产品被引用文献
Source Reference
- Mannoni, P. et al. (1982) Monoclonal antibodies against human granulocytes and myeloid differentiation antigens.
Hum Immunol. 5 (4): 309-23.
References for CD66b antibody
- Rosenkranz, A.R. et al. (1999) Novel C5-dependent mechanism of neutrophil stimulation by bioincompatible dialyzer membranes.
J Am Soc Nephrol. 10: 128-35. - Feuk-Lagerstedt, E. et al. (1999) Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils.
J Immunol. 163: 5592-8. - Ottonello, L. et al. (1999) Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins.
Blood. 93: 3505-11. - Ottonello, L. et al. (2000) Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of FcgammaRII-dependent cytolysis.
J Leukoc Biol. 68: 662-8. - Jankowski, A. et al. (2002) Determinants of the phagosomal pH in neutrophils.
J Biol Chem. 277: 6059-66. - Thickett, D.R. et al. (2002) A role for vascular endothelial growth factor in acute and resolving lung injury.
Am J Respir Crit Care Med. 166: 1332-7. - Jinnouchi, A. et al. (2005) Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms.
J Leukoc Biol. 78: 1356-65. - Sekine, K. et al. (2006) Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides.
J Immunol Methods. 313: 96-109.
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Mouse anti Human CD66b，clone 80H3
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