- 询价
- BIO-RAD
- MCA2486
- 2025年10月17日
- E, P *, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human MCP-1/MCAF ( PHP061)
- 亚型：
IgG1
- 形态：
Purified IgG - lyophilized
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
2.2-4H5-1A11
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E, P *, WB
- 浓度：
IgG concentration 1.0 mg/ml after reconstitution
- 抗体名：
MCP-1 antibody | 2.2-4H5-1A11
- 规格：
0.5 mg
Mouse anti Human MCP-1 antibody, clone 2.2-4H5-1A11 recognizes human C-C motif chemokine 2, also known as Monocyte chemoattractant protein 1 (MCP-1), Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2 or CCL2, and does not cross react with MCP-2, MCP-3 or other structurally related chemokines. MCP-1 is a 99 amino acid, including a 23 aa signal peptide ~13 kDa chemotactic protein, a chemoattractant for monocytes and basophils but not neutrophils or eosinophils (Weber et al.1996).
MCP-1 is produced by a number of cell types, including monocytes, macrophages, microglia, fibroblasts and epithelial cells (Cushing et al. 1990). MCP-1 influences T-cell immunity polarizing responses towards the Th2 phenotype (Karpus and Kennedy 1997). Variations in the CCL2 gene affects susceptibility to Mycobacteriun tuberculosis infection (Flores-Villanueva et al. 2005).
Mouse anti Human MCP-1 antibody, clone 2.2-4H5-1A11 recognizes both native MCP-1 and recombinant MCP-1
MCP-1 is produced by a number of cell types, including monocytes, macrophages, microglia, fibroblasts and epithelial cells (Cushing et al. 1990). MCP-1 influences T-cell immunity polarizing responses towards the Th2 phenotype (Karpus and Kennedy 1997). Variations in the CCL2 gene affects susceptibility to Mycobacteriun tuberculosis infection (Flores-Villanueva et al. 2005).
Mouse anti Human MCP-1 antibody, clone 2.2-4H5-1A11 recognizes both native MCP-1 and recombinant MCP-1
储存信息
This product is shipped at ambient temperature.
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | 1.0 | 2.0ug/ml |
| Immunohistology - Paraffin 1 | ✓ | 10ug/ml | |
| Western Blotting | ✓ | 0.2 | 0.4ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- ELISA
- This product may be used in an indirect ELISA or as a capture antibody in a sandwich ELISA together with PHP061 as the standard.
- Histology Positive Control Tissue
- Human Breast Invasive Ductal Carcinoma
- Western Blotting
- This product may be used under either reducing or non-reducing conditions together with PHP061 as the positive control.
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文献和实验该产品被引用文献
References for MCP-1 antibody
- Johansson, U. et al. (2008) Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization.
Diabetes. 57: 2393-401. - Nio-Kobayashi J et al. (2015) Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis.
Mol Hum Reprod. pii: gav028. - Chuang, L.P. et al. (2016) Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia.
Sleep Breath. 20 (1): 425-33.
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Mouse anti Human MCP-1，clone 2.2-4H5-1A11
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