- 询价
- BIO-RAD
- AHP3070
- 2025年10月17日
- Ch, IF, P, WB
- Human
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- 详细信息
- 技术资料
- 亚型：
Histone H4 (Ac)
- 形态：
Purified IgG - liquid
- 克隆性：
Polyclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
Polyclonal IgG
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
Ch, IF, P, WB
- 抗体名：
Histone H4 (Ac) antibody
- 规格：
0.1 mg
Rabbit anti Human histone H4 (Ac) antibody recognizes acetylated histone H4.
Histone H4 is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histones may be modified in several ways including acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and SUMOylation (Koch et al. 2007). Lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Hyperacetylation of histone tails makes chromatin more accessible to DNA-binding proteins by weakening histone-DNA and nucleosome-nucleosome interactions (Kuo and Allis, 1998) and therefore, is often associated with transcriptional activation.
Rabbit anti Human histone H4 (Ac) antibody has been shown to not react with histone H2A in HeLa cells. Wide species cross-reactivity is expected based on sequence
Histone H4 is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). Histones may be modified in several ways including acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and SUMOylation (Koch et al. 2007). Lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Hyperacetylation of histone tails makes chromatin more accessible to DNA-binding proteins by weakening histone-DNA and nucleosome-nucleosome interactions (Kuo and Allis, 1998) and therefore, is often associated with transcriptional activation.
Rabbit anti Human histone H4 (Ac) antibody has been shown to not react with histone H2A in HeLa cells. Wide species cross-reactivity is expected based on sequence
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Chromatin Immunoprecipitation | ✓ | 5 μg per ChIP | 10 μg per ChIP |
| Immunofluorescence | ✓ | 1 μg/ml | 2 µg/ml |
| Immunohistology - Paraffin | ✓ | 1/1000 | |
| Western Blotting | ✓ | 1 μg/ml | 2 μg/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Rabbit anti Human Histone H4 (Ac)
询价
