- 询价
- BIO-RAD
- MCA1283
- 2025年10月17日
- F, FN *, P, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
C5aR - peptide: Met1 - Asn31.
- 亚型：
IgG2a
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
S5/1
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F, FN *, P, WB
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
CD88 antibody | S5/1
- 规格：
0.2 mg
Mouse anti Human CD88 antibody, clone S5/1 recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21).
Clone S5/1 has been shown to inhibit the binding of C5a to its receptor.
Clone S5/1 has been shown to inhibit the binding of C5a to its receptor.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | 1/50 | 1/100 |
| Functional Assays 1 | ✓ | ||
| Immunohistology - Frozen | × | ||
| Immunohistology - Paraffin | ✓ | ||
| Immunoprecipitation | × | ||
| Western Blotting | ✓ |
- 1 Bio-Rad recommend the use of MCA1283EL for functional studies.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 5 x 105 cells in 100μl
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文献和实验该产品被引用文献
Source Reference
- Oppermann, M. et al. (1993) Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain.
J Immunol. 151: 3785-94.
References for CD88 antibody
- Oppermann, M. & Götze, O. (1994) Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors.
Immunology. 82 (4): 516-21. - Oppermann, M. et al. (1995) Antibodies from the myeloid panel that react with the C5a receptor and antagonize C5a biological activity.
In: Schlossman, S.F. (ed.) Leucocyte Typing V. O.U.P. pp 955-956. - Werfel, T. et al. (1996) CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.
J Immunol. 157 (4): 1729-35. - Thivierge, M. et al. (1999) Modulation of formyl peptide receptor expression by IL-10 in human monocytes and neutrophils.
J Immunol. 162: 3590-5. - Eglite, S. et al. (2000) Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils.
J Immunol. 165: 2183-9. - Kraft, K. et al. (2001) Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.
J Biol Chem. 276: 34408-18. - Sumichika, H. et al. (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist.
J Biol Chem. 277: 49403-7. - Huang, L. et al. (2005) Discovery of human antibodies against the C5aR target using phage display technology.
J Mol Recognit.18: 327-33.
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文献支持
Mouse anti Human CD88，clone S5/1
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