- 询价
- BIO-RAD
- TZA061P
- 2025年10月17日
- E
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 免疫原：
Romosozumab
- 亚型：
Fab antibody
- 形态：
A bivalent human recombinant Fab (kappa light chain) generated by coupling of the monovalent SpyTagged Fab TZA061 with a HRP conjugated BiSpyCatcher version 2. The coupled antibody has two DYKDDDDK tags and three His6-tags. It contains SpyTag3 peptide (BLP086) in 5-fold molar excess to block any unreacted Catcher sites. This antibody is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
HRP
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD60146
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
Romosozumab antibody | AbD60146
- 规格：
0.1 mg
Human Anti-Romosozumab Antibody, clone AbD60146 is a paratope specific, inhibitory, anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug romosozumab, and its biosimilar products. It does not recognize the drug target, sclerostin, nor romosozumab in complex with sclerostin. This antibody can be used to measure free romosozumab levels in serum from patients.
Clone AbD60146 is available as a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog under product code TZA061. It is also available as a bivalent Fab antibody already conjugated to HRP via coupling to the HRP conjugated BiSpyCatcher2 (TZC002P) for use in direct ELISA under product code TZA061P.
A pair of anti-romosozumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug; clone AbD60146 is recommended as a detection antibody, paired with Human Anti-Romosozumab Antibody, clone AbD60141ad (TZA060) as the capture reagent.
Romosozumab (trade name Evenity) is a humanized monoclonal antibody of the IgG2/kappa isotype that binds to sclerostin and prevents inhibition of the Wnt signaling pathway, thereby promoting osteogenesis and, to a lesser extent, reducing bone resorption. Romosozumab's inhibition of sclerostin also inhibits the increase in RANKL-dependent increases in osteoclast activity and bone resorption. Romosozumab is indicated for the treatment of osteoporosis in postmenopausal women at high risk for fracture.
Clone AbD60146 is available as a monovalent Fab antibody incorporating a SpyTag at the C-terminus end of the antibody heavy chain for conversion by the end user into alternative formats using any of the SpyCatchers available in our catalog under product code TZA061. It is also available as a bivalent Fab antibody already conjugated to HRP via coupling to the HRP conjugated BiSpyCatcher2 (TZC002P) for use in direct ELISA under product code TZA061P.
A pair of anti-romosozumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug; clone AbD60146 is recommended as a detection antibody, paired with Human Anti-Romosozumab Antibody, clone AbD60141ad (TZA060) as the capture reagent.
Romosozumab (trade name Evenity) is a humanized monoclonal antibody of the IgG2/kappa isotype that binds to sclerostin and prevents inhibition of the Wnt signaling pathway, thereby promoting osteogenesis and, to a lesser extent, reducing bone resorption. Romosozumab's inhibition of sclerostin also inhibits the increase in RANKL-dependent increases in osteoclast activity and bone resorption. Romosozumab is indicated for the treatment of osteoporosis in postmenopausal women at high risk for fracture.
储存信息
This product is shipped frozen.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols for coupling a Fab antibody with a SpyTag to a SpyCatcher can be found at SpyTag and SpyCatcher Products, and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual
- ELISA
-
Clone AbD60146pap can be used in direct ELISA to detect romosozumab. It can also be used as a detection antibody to develop a pharmacokinetic (PK) bridging ELISA for romosozumab together with TZA060 as the capture reagent.
Protocol: PK bridging ELISA
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Human anti Romosozumab:HRP，clone AbD60146
询价
