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- BIO-RAD
- TZA057P
- 2025年10月17日
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- 详细信息
- 技术资料
- 免疫原：
Monomethyl Auristatin E (MMAE)
- 亚型：
Fab antibody
- 形态：
A bivalent human recombinant Fab (kappa light chain) generated by coupling of the monovalent SpyTagged Fab TZA057 with a HRP conjugated BiSpyCatcher version 2 (TZC002P). The coupled antibody has two DYKDDDDK tags and three His6-tags. It contains SpyTag3 peptide (BLP086) in 5-fold molar excess to block any unreacted Catcher sites. This antibody is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
HRP
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD50348
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
Antibody concentration 0.5 mg/ml
- 抗体名：
MMAE antibody | AbD50348
- 规格：
0.1 mg
Human Anti-MMAE Antibody, clone AbD50348 recognizes the Monomethyl Auristatin E (MMAE) toxin, an antimitotic agent which inhibits cell division by blocking the polymerization of tubulin. Because of its toxicity, MMAE is not used as a drug itself, but is rather linked to monoclonal antibodies to form an antibody-drug conjugate through a cathepsin-cleavable linker that is stable in the extracellular fluid. Upon binding into the target cell, the linker is cleaved by cathepsin, realeasing the toxin in the cell and activating the antimitotic mechanism.
This antibody is tagged with a SpyTag2 at the C-terminus of the Fab antibody heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour.
View a summary of SpyCatcher products
Human anti-MMAE Antibody, clone AbD50348 has been shown to recognize the MMAE toxin in both free and antibody-conjugated forms. It has also been shown to cross-react with the MMAE closely related toxin MMAF and MMAD. It does not recognize unbound antibody drugs. Clone AbD50348 can therefore be used to measure the level of several MMAE bound drug in serum from patients.
View a summary of all MMAE antibodies
This antibody is tagged with a SpyTag2 at the C-terminus of the Fab antibody heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour.
View a summary of SpyCatcher products
Human anti-MMAE Antibody, clone AbD50348 has been shown to recognize the MMAE toxin in both free and antibody-conjugated forms. It has also been shown to cross-react with the MMAE closely related toxin MMAF and MMAD. It does not recognize unbound antibody drugs. Clone AbD50348 can therefore be used to measure the level of several MMAE bound drug in serum from patients.
View a summary of all MMAE antibodies
储存信息
This product is shipped frozen.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols for coupling a Fab antibody with a SpyTag to a SpyCatcher can be found at SpyTag and SpyCatcher Products, and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual
- ELISA
-
Clone AbD50348pap can be used as the detection antibody for MMAE toxin in its free and also in its coupled format eg. brentuximab vedotin, in a PK ELISA together with TZA056 as the capture antibody.
Protocol: PK bridging ELISA
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Human anti MMAE:HRP，clone AbD50348
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