- 询价
- BIO-RAD
- HCA185G
- 2025年10月17日
- E
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Bevacizumab
- 亚型：
IgG1
- 形态：
Human IgG1 antibody selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 保质期：
自发货之日起 12 个月
- 目录编号：
AbD17976_hIgG1
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
HCA185G: Total protein concentration 1.0 mg/ml
- 抗体名：
Bevacizumab antibody | AbD17976_hIgG1
- 规格：
1 mg/0.1 mg
| 规格： | 1 mg | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 0.1 mg | 产品价格： | 询价 |
Human Anti-Bevacizumab Antibody, clone AbD17976_hIgG1 is an affinity-matured, inhibitory, anti-idiotypic antibody that recognizes the humanized monoclonal antibody drugs bevacizumab and ranibizumab, and their biosimilar products.
Clone AbD17976_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a positive control or calibrator in an anti-drug antibody (ADA) assay.
This Anti-Bevacizumab Antibody cross-reacts with the drug ranibizumab (Lucentis). Ranibizumab is a humanized Fab fragment antibody (VH3-23/kappa1), originating from the same parental mouse antibody as bevacizumab; it has 4 amino acid exchanges in the heavy chain and 1 amino acid exchange in the light chain compared to bevacizumab.
Bevacizumab (trade name Avastin) is a humanized monoclonal antibody (IgG1/kappa) that inhibits angiogenesis by binding to vascular endothelial growth factor alpha (VEGF-A). VEGF-A is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis. Bevacizumab is used to treat various cancers, including colorectal, lung, breast, glioblastoma, kidney and ovarian.
View a summary of all anti-bevacizumab antibodies.
Clone AbD17976_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a positive control or calibrator in an anti-drug antibody (ADA) assay.
This Anti-Bevacizumab Antibody cross-reacts with the drug ranibizumab (Lucentis). Ranibizumab is a humanized Fab fragment antibody (VH3-23/kappa1), originating from the same parental mouse antibody as bevacizumab; it has 4 amino acid exchanges in the heavy chain and 1 amino acid exchange in the light chain compared to bevacizumab.
Bevacizumab (trade name Avastin) is a humanized monoclonal antibody (IgG1/kappa) that inhibits angiogenesis by binding to vascular endothelial growth factor alpha (VEGF-A). VEGF-A is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis. Bevacizumab is used to treat various cancers, including colorectal, lung, breast, glioblastoma, kidney and ovarian.
View a summary of all anti-bevacizumab antibodies.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
-
This product is suitable for use in direct ELISA applications.
This antibody is fully human and can be used as a reference standard in an ADA assay.
Protocol: ADA bridging ELISA.
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文献和实验该产品被引用文献
References for Bevacizumab antibody
- Iwamoto, N. et al. (2018) Antibody drug quantitation in coexistence with anti-drug antibodies on nSMOL bioanalysis.
Anal Biochem. 540-541: 30-7.
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文献支持
Human anti Bevacizumab，clone AbD17976_hIgG1
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