- 询价
- BIO-RAD
- MCA6229B
- 2025年10月17日
- E
- Human
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- 详细信息
- 技术资料
- 免疫原：
Purified native human complement factor H
- 亚型：
IgG1
- 形态：
Purified IgG conjugated to Biotin - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Biotin
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
C01-4A10
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E
- 浓度：
IgG concentration 0.1 mg/ml
- 抗体名：
Complement Factor H antibody | C01-4A10
- 规格：
0.1 mg
Mouse anti Human complement Factor H antibody, clone C01-4A10, recognizes, complement factor H, also known as H Factor1. Complement factor H is a major regulatory protein of the alternative activation pathway of the complement cascade. It regulates this pathway by targeting C3 convertase (C3bBb) for degradation and by acting as a co-factor in the cleavage and inactivation of C3b. Complement factor H is a soluble ~155 kDa glycoprotein present in serum at a relatively high concentration, averaging between 200 – 800 ug/ml. It is also expressed locally by many cells types including epithelial cells and platelets (Ferreira et al. 2010, Parente et al. 2017).
Due to the major regulatory functionality of complement factor H, mutations and polymorphisms of the encoding gene are associated with inappropriate recognition of “self” cell markers in patients and consequently results in complement mediated tissue damage and disease. These mutations are associated with various diseases including atypical haemolytic uremic syndrome and C3 glomerulophathy (Martinez-Barricate et al. 2008, Cserhalmi et al. 2017).
The biotinylated Mouse anti Human complement factor H antibody, clone C01-4A10 (MCA6229B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human complement factor H antibody, clone C06-2F3 (MCA6228GA) as the capture antibody.
Due to the major regulatory functionality of complement factor H, mutations and polymorphisms of the encoding gene are associated with inappropriate recognition of “self” cell markers in patients and consequently results in complement mediated tissue damage and disease. These mutations are associated with various diseases including atypical haemolytic uremic syndrome and C3 glomerulophathy (Martinez-Barricate et al. 2008, Cserhalmi et al. 2017).
The biotinylated Mouse anti Human complement factor H antibody, clone C01-4A10 (MCA6229B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human complement factor H antibody, clone C06-2F3 (MCA6228GA) as the capture antibody.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | 1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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技术资料暂无技术资料 索取技术资料
Mouse anti Human Complement Factor H:Biotin，clone C01-4A10
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