- 询价
- BIO-RAD
- MCA1742
- 2025年10月17日
- C, E, F, IF, P *, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Urinary MUC-1 mucin.
- 亚型：
IgG3
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
C595 (NCRC48)
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
C, E, F, IF, P *, WB
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
CD227 antibody | C595 (NCRC48)
- 规格：
0.2 mg
Mouse anti Human CD227 antibody, clone C595 (NCRC48) recognizes CD227, also known as mucin 1 which is a breast cancer associated mucin encoded by the Muc-1 gene. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by many epithelial tissues in vertebrates. CD227 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. This protein is overexpressed abundantly in >90% breast carcinomas and metastases.
Mouse anti Human CD227 antibody, clone C595 recognizes the peptide epitope ARG-PRO-ALA-PRO within the protein core of the mucin.
Mouse anti Human CD227 antibody, clone C595 recognizes the peptide epitope ARG-PRO-ALA-PRO within the protein core of the mucin.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | 1/100 | 1/1000 |
| Flow Cytometry | ✓ | ||
| Immunofluorescence | ✓ | ||
| Immunohistology - Frozen | ✓ | ||
| Immunohistology - Paraffin 1 | ✓ | ||
| Western Blotting | ✓ |
- 1This product requires heat mediated antigen retrieval prior to staining of paraffin embedded material. Citrate buffer pH6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human breast carcinoma
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文献和实验该产品被引用文献
Source Reference
- Price, M.R. et al. (1990) C595--a monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinomas.
Br J Cancer. 61 (5): 681-6.
References for CD227 antibody
- Price, M.R. et al. (1990) Immunological and structural features of the protein core of human polymorphic epithelial mucin.
Mol Immunol. 27 (8): 795-802. - Price, M.R. et al. (1991) Purification of anti-epithelial mucin monoclonal antibodies by epitope affinity chromatography.
J Immunol Methods. 139 (1): 83-90. - Denton, G. et al. (1995) Primary sequence determination and molecular modelling of the variable region of an antiMUC1 mucin monoclonal antibody.
Eur J Cancer. 31A (2): 214-21. - Denton, G. et al. (1997) Production and characterization of a recombinant anti-MUC1 scFv reactive with human carcinomas.
Br J Cancer. 76 (5): 614-21. - Murray, A. et al (2001) Production and characterization of 188Re-C595 antibody for radioimmunotherapy of transitional cell bladder cancer.
J Nucl Med. 42: 726-32. - Huang, D.M. et al. (2004) Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells.
Prostate. 2004 May 15;59(3): 260-7. - Ragupathi, G. et al. (2005) Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity.
J Immunol. 174: 5706-12. - Hisatsune, A. et al. (2011) Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells.
Biochem Biophys Res Commun. 405: 377-81.
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文献支持
Mouse anti Human CD227，clone C595 (NCRC48)
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