- 询价
- BIO-RAD
- MCA6165GA
- 2025年10月17日
- F
- Pig
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
NIH/3T3 mouse cells transfected with plasmid pTLR2-GFP, encoding the porcine TLR2 tagged with the green fluorescent protein (GFP) on the carboxy-terminal end
- 亚型：
IgG1
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Pig
- 保质期：
自发货之日起 12 个月
- 目录编号：
1H11
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F
- 浓度：
IgG concentration 1.0 mg/ml
- 抗体名：
CD282 antibody | 1H11
- 规格：
0.1 mg
Mouse anti Pig CD282, clone 1H11 recognizes CD282, also known as toll-like receptor 2 (TLR2).
Toll like receptors are a family of pattern-recognition receptors involved in the activation and regulation of inflammatory and immune responses activated by invasion of host tissues by microbial pathogens. TLR2 plays a role in a range of infections including gram-positive bacteria, mycobacteria, and yeast. It is activated by PAMPs, signals to NF-kappa-B which in turn induces cytokine secretion and the inflammatory response.
Clone 1H11 was used to characterize the expression of porcine TLR2; cells of the innate immune system - monocytes, macrophages, and granulocytes, but not on peripheral blood lymphocytes were found to express porcine TLR2. Swine neutrophils express low levels of TLR2. It is also expressed on epithelial cells lining the tracheobronchial and intestinal tracts, bile ducts in the liver and renal tubules, and on the basal layer of the epidermis (Alvarez et al 2008).
Toll like receptors are a family of pattern-recognition receptors involved in the activation and regulation of inflammatory and immune responses activated by invasion of host tissues by microbial pathogens. TLR2 plays a role in a range of infections including gram-positive bacteria, mycobacteria, and yeast. It is activated by PAMPs, signals to NF-kappa-B which in turn induces cytokine secretion and the inflammatory response.
Clone 1H11 was used to characterize the expression of porcine TLR2; cells of the innate immune system - monocytes, macrophages, and granulocytes, but not on peripheral blood lymphocytes were found to express porcine TLR2. Swine neutrophils express low levels of TLR2. It is also expressed on epithelial cells lining the tracheobronchial and intestinal tracts, bile ducts in the liver and renal tubules, and on the basal layer of the epidermis (Alvarez et al 2008).
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul
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文献和实验该产品被引用文献
Source Reference
- Alvarez, B. et al. (2008) Expression of toll-like receptor 2 (TLR2) in porcine leukocyte subsets and tissues.
Vet Res. 39 (2): 13.
References for CD282 antibody
- Álvarez-Estrada, Á. et al. (2019) TLR2, Siglec-3 and CD163 expressions on porcine peripheral blood monocytes are increased during sepsis caused by Haemophilus parasuis.
Comp Immunol Microbiol Infect Dis. 64: 31-39. - Álvarez, B. et al. (2023) Porcine Macrophage Markers and Populations: An Update.
Cells. 12 (16): 2103.
Further Reading
- Alvarez, B. et al. (2013) Antigen targeting to APC: from mice to veterinary species.
Dev Comp Immunol. 41 (2): 153-63.
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文献支持
Mouse anti Pig CD282，clone 1H11
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