- 询价
- BIO-RAD
- MCA4636GA
- 2025年10月17日
- E, F, IF, IP, WB
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Extracellular portion of mouse CD152 fused to a mouse IgG2a.
- 亚型：
IgG
- 形态：
Purified IgG - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
Purified
- 适应物种：
Mouse
- 保质期：
自发货之日起 12 个月
- 目录编号：
1B8
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
E, F, IF, IP, WB
- 浓度：
IgG concentration 1.0mg/ml
- 抗体名：
CD152 antibody | 1B8
- 规格：
0.1 mg
Hamster anti Mouse CD152 antibody, clone 1B8 recognizes mouse CD152, also known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naïve T-cells and is induced upon T-cell activation.
In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis.
Hamster anti Mouse CD152 antibody, clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumor immunity.
In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis.
Hamster anti Mouse CD152 antibody, clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumor immunity.
储存信息
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | ✓ | ||
| Flow Cytometry | ✓ | 1/10 | 1/100 |
| Immunofluorescence | ✓ | ||
| Immunoprecipitation | ✓ | ||
| Western Blotting | ✓ |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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文献和实验该产品被引用文献
References for CD152 antibody
- Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation.
Immunity 1: 405-413. - Verhagen, J. et al. (2013) CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Proc Natl Acad Sci U S A. 110 (3): E221-30.
Further Reading
- Karandikar, N.J. et al. (1996) CTLA-4: a negative regulator of autoimmune disease.
J Exp Med. 184 (2): 783-8.
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文献支持
Hamster anti Mouse CD152，clone 1B8
询价
