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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-4989R |
| 英文名称 | BDNF Rabbit pAb |
| 中文名称 | 脑源神经营养因子抗体 |
| 英文别名 | Abrineurin; BDNF; BDNF; BDNF_HUMAN; Brain Derived Neurotrophic Factor; Brain-derived neurotrophic factor; MGC34632; MGC34632; Neurotrophin. |
| 产品应用 | WB=1:500-2000, IHC-P=1:50-200, IHC-F=1:50-200, IF=1:50-200 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human BDNF |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 13/27 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Atherosclerosis > Diabetes associated Cardiovascular > Atherosclerosis > Thrombosis Metabolism > Types of disease > Diabetes Metabolism > Types of disease > Obesity Neuroscience > Neurology process > Growth and Development > Neurotrophins Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Neuroscience > Neurology process > Neurodegenerative disease > Huntington's disease Signal Transduction > Antibodies > bdnf |
| 亚基 | Monomers and homodimers. Binds to NTRK2/TRKB. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. |
| 翻译后修饰 | The propeptide is N-glycosylated and glycosulfated. |
| 相似性 | Belongs to the NGF-beta family. |
| 功能 | During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. More recently, three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4), also designated NT-5. These various neurotrophins stimulate the in vitro survival of distinct but partially overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds equally well to both BDNF and NT-4 and to a lesser extent NT-3, while the Trk C receptor only binds NT-3. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Belongs to the NGF-beta family. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:50-200} |
| {IHC-F} | {1:50-200} |
| {IF} | {1:50-200} |
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文献和实验[IF={{ 9.584 }}] {Liu Sumei. et al. Suppression of TGFβR-Smad3 pathway alleviates the syrinx induced by syringomyelia. CELL BIOSCI. 2023 Dec;13(1):1-13} {IF} {Rat}
[IF={{ 7.59 }}] {Yuanxin Zhai. et al. High-efficiency Brain-targeted Intranasal Delivery of BDNF Mediated by Engineered Exosomes to Promote Remyelination. BIOMATER SCI-UK. 2022 Aug;:} {IF} {Mouse}
[IF={{ 7 }}] {Pallavi Gurung. et al. Euonymus alatus Leaf Extract Attenuates Effects of Aging on Oxidative Stress, Neuroinflammation, and Cognitive Impairment. ANTIOXIDANTS-BASEL. 2024 Apr;13(4):433} {WB} {Mouse,Human,Rat}
[IF={{ 6.706 }}] {Pallavi Gurung. et al. Euonymus alatus Twig Extract Protects against Scopolamine-Induced Changes in Brain and Brain-Derived Cells via Cholinergic and BDNF Pathways. NUTRIENTS. 2023 Jan;15(1):128} {WB} {Mouse, Rat}
[IF={{ 6.208 }}] {Sheng-Hua Wu. et al. Spinal Irisin Gene Delivery Attenuates Burn Injury-Induced Muscle Atrophy by Promoting Axonal Myelination and Innervation of Neuromuscular Junctions. INT J MOL SCI. 2022 Jan;23(24):15899} {IF} {Rat}
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
基因-2(BCL-2) ELISA 48T/96T 1500/2500 进口分装 F0017 脑衍化神经营养因子(BDNF) ELISA 48T/96T 1800/2800 进口分装 F0018 骨成型蛋白-2(BMP-2) ELISA 48T/96T 2000/3000 进口分装 F0019 骨成型蛋白-4(BMP-4) ELISA 48T/96T 2000/3000 进口分装 F0020 骨成型蛋白-7(BMP-7) ELISA 48T
基因-2(BCL-2) ELISA 48T/96T 1500/2500 进口分装 F0017 脑衍化神经营养因子(BDNF) ELISA 48T/96T 1800/2800 进口分装 F0018 骨成型蛋白-2(BMP-2) ELISA 48T/96T 2000/3000 进口分装 F0019 骨成型蛋白-4(BMP-4) ELISA 48T/96T 2000/3000 进口分装 F0020 骨成型蛋白-7(BMP-7) ELISA 48T
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