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- bs-0016R
- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-0016R |
| 英文名称 | Tyrosine Hydroxylase Rabbit pAb |
| 中文名称 | 酪氨酸羟化酶抗体 |
| 英文别名 | DYT14; DYT5b; ple; Protein Pale; c; The; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyk2; TY3H_HUMAN; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse TH |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 60 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cancer > Cancer Metabolism > Response to hypoxia Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Neuroscience > Cell Type Marker > Neuron marker > Soma marker Neuroscience > Neurotransmitter > Biogenic Amines > Dopamine Neuroscience > Neurotransmitter > Biogenic Amines > Noradrenaline |
| 亚基 | Homotetramer. |
| 亚细胞定位 | Mainly expressed in the brain and adrenal glands. |
| 组织特异性 | Mainly expressed in the brain and adrenal glands. |
| 翻译后修饰 | In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. |
| 相似性 | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
| 功能 | Plays an important role in the physiology of adrenergic neurons. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-0016P is one synthetic peptide derived from human TH. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 6.35 }}] {Yue Y et al. Noradrenaline-Specific, Efficient Visualization in Brain Tissue Triggered by Unique Cascade Nucleophilic Substitution. Anal Chem. 2019 Feb 5;91(3):2255-2259.} {IF} {Mouse}
[IF={{ 5.811 }}] {Lang Xiu-Yuan. et al. Coeloglossum viride Var. Bracteatum Extract Attenuates MPTP-Induced Neurotoxicity in vivo by Restoring BDNF-TrkB and FGF2-Akt Signaling Axis and Inhibiting RIP1-Driven Inflammation. FRONT PHARMACOL. 2022 Apr;0:1571} {WB} {Mouse}
[IF={{ 5.6 }}] {Lu Yang. et al. Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65. INT IMMUNOPHARMACOL. 2023 Oct;123:110808} {WB} {Mouse}
[IF={{ 4.6 }}] {Dong Xiaolin. et al. Inhibition of tRF- 02514 in Extracellular Vesicles Preserves Microglia Pyroptosis and Protects Against Parkinson’s Disease. MOL NEUROBIOL. 2025 Apr;:1-17} {IHC} {Mouse}
[IF={{ 4.526 }}] {Wen Yi. et al. Suppression of axonal attractant netrin-1 injured dopaminergic neuronal and motor function of mice during manganese over-exposure. METALLOMICS. Metallomics. 2022 Apr;:} {WB} {Mouse}
rabbit serum albumin 兔血清白蛋白 R-Sc Reed-Sternberg's cell 瑞-司氏细胞 Z/R Reinheit Zahl 光密度比值 SAV small agranular vesicle 无颗粒小泡 SBA soybean agglutinin 大豆凝集素 SC secretory component 分泌成份 SCV small clear vesicle 清亮小泡 SDS sodium
.ahc.umn.edu/ Curated information on microbial catabolism and related biotransformations 162. PathDB http://www.ncgr.org/pathdb Biochemical pathways, compounds and metabolism 163. PRODORIC http://prodoric.tu-bs.de/ Prokaryotic database of gene
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