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- bs-0482PB
- 2025年10月16日
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1mg
| 产品编号 | bs-0482PB |
| 英文名称 | Gastrin(1-17)-BSA |
| 中文名称 | 胃泌素/蛙皮素BSA偶联物 |
| 英文别名 | Component II; GAS; GAST; Gastrin precursor. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 储存液 | 0.01M TBS(pH7.4). |
| 研究领域 | Cancer > Tumor biomarkers > Hormones Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment Cardiovascular > Blood Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. |
| 相似性 | Belongs to the gastrin/cholecystokinin family. |
| 功能 | Gastrin stimulates the stomach mucosa to produce and secrete ** and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Gastrin is responsible for epithelial cell proliferation and differentiation. Gastrin regulates the action of parietal cells in secretion of gastric acid and growth factors essential for stomach maintenance. Gastrin maintains sodium ion homeostasis and controls body’s blood pressure. Hypoxial conditions in in vitro and in vivo analysis may elevate the expression of gastrin hormone in cancer cells in order to promote angiogenesis. The only established clinical routine use of gastrin RIA so far is in the diagnosis, localization, and therapeutic control of gastrinomas (Zollinger–Ellison or Z–E tumors). |
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文献和实验一种胃肠激素。由存在于胃幽门部粘膜的 G细胞（ gastrin containing cell）分泌的，进入血中再作用于胃，促进胃液分泌。胃的幽门窦受到食物等的机械性刺激，幽门部的 pH偏碱性时就进行胃泌素的分泌。其结果，胃液特别是盐酸的分泌变得旺盛，而当胃内部的 pH降低时盐酸和胃泌素的分泌就停止。此外，胃泌素也具有促进胃蛋白酶分泌、胰液分泌、胆液分泌、胰岛素分泌等的作用，可是这些作用并不强。它系由 17个氨基酸残基组成的多肽，有两种：酪氨酸残基上为硫酸基取代的和未被取代
ESCO-0480 ESCO 螺丝刀EA557C-75 螺丝刀 EA557C-75
-0547 ESCO 剪钳EA536DA-150 EA536DA-150 ESCO-0546 ESCO 扳手EA546VB-2 EA546VB-2 ESCO-0545 ESCO 万用表EA707B-2 EA707B-2 ESCO-0544 ESCO 爪EA500AA-120 EA500AA-120 ESCO-0543 ESCO 磁铁座EA725T-40 EA725T-40 ESCO-0542 ESCO 万用表EA707D-17 EA707D-17 ESCO
认为溃疡复发。 2 结 果 A、B组溃疡愈合率分别为81.8％（18/22）及81.0％（17/21）。二者比较，差异无显著性（P＞0.05），A组的Hp根除率为59.1％（13/32）稍高于B组（42.9％，9/17），但二者比较，差异无显著性（P＞0.05）。Hp根除的病人100％（22/22），溃疡愈合率明显高于Hp未根除者16.9％，（13/21）（P＜0.05），而溃疡一年复发率Hp根除约为9.1％（2/22），则明显低于Hp未根除者（100％，13/13）（P
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