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- bs-8671P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-8671P |
| 英文名称 | MMS19 Antibody Blocking Peptide |
| 中文名称 | DNA修复甲**酸敏感性基因19封闭多肽 |
| 英文别名 | MET18MMS19 nucleotide excision repair homolog; methyl methanesulfonate sensitivity gene19; MMS19L; MMS-19L; MMS 19 nucleotide excision repair homolog MET18. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Nucl. Excision Repair Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription > TFIIH Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors |
| 亚基 | Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. |
| 亚细胞定位 | Nuclear. |
| 组织特异性 | Ubiquitously expressed with higher expression in testis. |
| 相似性 | Belongs to the MET18/MMS19 family. Contains 7 HEAT repeats. |
| 功能 | MMS19 like protein may play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. It may also function as a transcriptional coactivator of estrogen receptor (ER) and may be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types. It is ubiquitously expressed with higher expression in testis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MMS19 is a 1,030 amino acid nuclear protein containing seven HEAT repeats that belongs to the MET18/MMS19 family. Via its interactions with TFIIH p80 and TFIIH p89 helicases, MMS19 plays a role in nucleotide excision repair (NER) and RNA polymerase II (Pol II) transcription. MMS19 may also function as a transcriptional coactivator of estrogen receptor. While ubiquitously expressed, highest levels of MMS19 have been found in testis. At least five distinct MMS19 protein isoforms exist, which are produced by alternative splicing events. The gene encoding MMS19 maps to human chromosome 10q24.1, and is associated with the risk of pancreatic cancer. |
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MMS19 Antibody Blocking Peptide(bs-8671P)-500ug
￥880
