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- Bioss
- bs-17851P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-17851P |
| 英文名称 | MSH4 Antibody Blocking Peptide |
| 中文名称 | MSH4蛋白封闭多肽 |
| 英文别名 | MSH 4; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Mismatch Repair |
| 亚基 | Heterooligomer of MSH4 and MSH5. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Testis and ovary specific. |
| 相似性 | Belongs to the DNA mismatch repair MutS family. |
| 功能 | The Escherichia coli MutHLS system has been highly conserved throughout evolution. The eukaryotic pathway results in a specialization of MutS homologs such as MSH2 that have evolved to play crucial roles in both DNA mismatch repair and meiotic recombination. In Saccharomyces cerevisiae, MSH4 is a meiosis-specific protein that is not involved in mismatch correction. This protein is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] |
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MSH4 Antibody Blocking Peptide(bs-17851P)-500ug
￥880
