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- 2025年10月16日
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500ug
| 产品编号 | bs-17744P |
| 英文名称 | MPZL Antibody Blocking Peptide |
| 中文名称 | 髓鞘蛋白P0样蛋白1封闭多肽 |
| 英文别名 | immunoglobulin family transmembrane protein; MPZL1; MPZL1b; MPZL1_HUMAN; myelin protein zero like 1; myelin protein zero like protein 1 precursor; myelin protein zero like protein MPZL1b; OTTHUMP00000032519; protein zero related; PZR; PZR1b; PZRa; PZRb. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases |
| 亚基 | Interacts with phosphorylated PTPN11/SHP-2. |
| 亚细胞定位 | Membrane; single pass type I membrane protein (Potential) |
| 组织特异性 | Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. |
| 翻译后修饰 | Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro). N-glycosylated. |
| 相似性 | Belongs to the myelin P0 protein family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Cell surface receptor, which is involved in signal transduction processes. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine protein kinases. Isoform 3 seems to block tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, unlike isoforms 2 and 3, may be involved in regulation of integrin mediated cell motility. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MPZL1 is a 269 amino acid widely expressed single-pass type I membrane receptor belonging to the myelin P0 protein family and the immunoglobulin superfamily. MPZL2 (myelin protein zero-like 2), also known as EVA (epithelial V-like antigen) or EVA1, is a 215 amino acid single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain and two potential N-glycosylation sites in its extracellular domain, MPZL2 is expressed in thymus epithelium and is strongly down-regulated by thymocyte developmental progression. MPZL3 (myelin protein zero-like 3) is a 235 amino acid single-pass type I membrane protein that regulates homophilic cell-to-cell adhesion. A member of the myelin P0 protein family, MPZL3 contains one Ig-like V-type (immunoglobulin-like) domain and is expressed in brain, heart, liver and skin. g to the myelin P0 protein family and the immunoglobulin superfamily. Existing as four alternatively spliced isoforms, MPZL1 participates in signal transduction and cell migration. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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