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- Bioss
- bs-33268P
- 2025年10月16日
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500ug
| 产品编号 | bs-33268P |
| 英文名称 | JAK1 Antibody Blocking Peptide |
| 中文名称 | 蛋白质酪氨酸激酶JAK-1封闭多肽 |
| 英文别名 | JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; JAK1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Signal transducers Cancer > Signal transduction > Protein phosphorylation > Tyrosine kinases Cell Biology > Apoptosis > Intracellular > Kinases Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Signal Transduction > Protein Phosphorylation > Tyrosine Kinases |
| 亚基 | Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB. |
| 亚细胞定位 | Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. |
| 组织特异性 | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 2 protein kinase domains. Contains 1 SH2 domain. |
| 功能 | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. |
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JAK1 Antibody Blocking Peptide(bs-33268P)-500ug
￥880
