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- Bioss
- bs-9902P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9902P |
| 英文名称 | NSFL1C Antibody Blocking Peptide |
| 中文名称 | 血小板p47蛋白封闭多肽 |
| 英文别名 | FLJ27168; OTTHUMP00000159962; P47; Platelet 47 kDa protein; Platelet and leukocyte C kinase substrate; Platelet P47; Platelet p47 protein; Pleckstrin; PLEK; PLEK_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > ER Proteins |
| 亚细胞定位 | Nucleus. Golgi apparatus > Golgi stack. Chromosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. |
| 组织特异性 | Major protein kinase C substrate of platelets. |
| 翻译后修饰 | Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis. |
| 相似性 | Contains 1 DEP domain. Contains 2 PH domains. |
| 功能 | Major protein kinase C substrate of platelets. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events. |
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NSFL1C Antibody Blocking Peptide(bs-9902P)-500ug
￥880
