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- bs-4453P
- 2025年10月16日
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500ug
| 产品编号 | bs-4453P |
| 英文名称 | SEC31A Antibody Blocking Peptide |
| 中文名称 | 转运蛋白SEC31A封闭多肽 |
| 英文别名 | 1810024J13Rik; ABP125; ABP130; AU042160; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; MGC93320; Protein transport protein Sec31A; SEC31 homolog A (S. cerevisiae); SEC31 like 1; SEC31 like protein 1; SEC31 related protein A; SEC31L1; VAP1; Web1 like protein; Yeast Sec31p homolog. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > ER Proteins Signal Transduction > Protein Trafficking > Organelle Proteins Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. |
| 组织特异性 | Cytoplasm. Cytoplasmic vesicle; COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Note: Associates with membranes in a GTP-dependent manner. |
| 翻译后修饰 | Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats. |
| 相似性 | Belongs to the WD repeat SEC31 family. Contains 8 WD repeats. |
| 功能 | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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SEC31A Antibody Blocking Peptide(bs-4453P)-500ug
￥880
