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- bs-9849P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9849P |
| 英文名称 | BAALC Antibody Blocking Peptide |
| 中文名称 | 脑和急性白血病胞浆蛋白封闭多肽 |
| 英文别名 | BAALC; BAALC_HUMAN; Brain and acute leukemia cytoplasmic; Brain and acute leukemia cytoplasmic protein; brain and acute leukemia, cytoplasmic; FLJ12015. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with CAMK2A (By similarity). |
| 亚细胞定位 | Cytoplasm. Membrane. Postsynaptic lipid rafts. |
| 组织特异性 | Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin. |
| 翻译后修饰 | Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity). |
| 功能 | May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | BAALC is a 180 amino acid protein that localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKII and is thought to play a role in synaptic function at postsynaptic lipid rafts. BAALC may be overexpressed in acute myeloid leukemia (AML), suggesting a role in tumorigenesis. The gene encoding BAALC maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8. |
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BAALC Antibody Blocking Peptide(bs-9849P)-500ug
￥880
