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HCFC2 Antibody Blocking Peptid

e(bs-9843P)-500ug
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  • 2025年10月16日
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      500ug

    产品编号bs-9843P
    英文名称HCFC2 Antibody Blocking Peptide
    中文名称肝素辅助因子II封闭多肽
    英文别名HC II; HCF2; HLS2; Leuserpin 2; LS2; Protease inhibitor leuserpin 2; SERPIND1; HEP2_HUMAN.
    纯化方法HPLC
    研究领域

    Cardiovascular > Blood

    Cardiovascular > Blood > Fibrinolysis / Thrombolysis

    亚细胞定位Cytoplasm. Nucleus.
    组织特异性Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.
    翻译后修饰Phosphorylation sites are present in the extracellular medium.
    相似性Contains 3 fibronectin type-III domains.
    Contains 4 Kelch repeats.
    功能Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

     

     

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