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- bs-9765P
- 2025年10月16日
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500ug
| 产品编号 | bs-9765P |
| 英文名称 | phospho-STMN1 (Ser24) Antibody Blocking Peptide |
| 中文名称 | 磷酸化原癌基因蛋白18封闭多肽 |
| 英文别名 | Stathmin 1 (phospho S24); p-Stathmin 1 (phospho S24); Stathmin 1 (Phospho-Ser24); Stathmin (Phospho Ser24); Stathmin (Phospho S24); Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; OP18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; PP17; PP19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; STMN1; STMN1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > Cytoskeletal Proteins > Microtubules Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > Tubulin |
| 亚基 | Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST. |
| 亚细胞定位 | Cytoplasm; cytoskeleton. |
| 组织特异性 | Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. |
| 翻译后修饰 | Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. |
| 相似性 | Belongs to the stathmin family. |
| 功能 | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
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phospho-STMN1 (Ser24) Antibody Blocking Peptide(bs-9765P)-500ug
￥1080
