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- 2025年10月16日
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| 产品编号 | bs-4120P |
| 英文名称 | MHC class I antigen B 15 Antibody Blocking Peptide |
| 中文名称 | 组织相关抗原HLA-B15封闭多肽 |
| 英文别名 | HLA-B15;HLA class I histocompatibility antigen B 13 alpha chain precursor; HLA class I histocompatibility antigen B 15 alpha chain precursor; MHC class I antigen B 13; MHC class I antigen B 15. |
| 纯化方法 | HPLC |
| 亚基 | Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein |
| 亚细胞定位 | Cell Membrane, single pass type I membrane protein. |
| 翻译后修饰 | Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system |
| 相似性 | Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
| 功能 | HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] |
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文献和实验Studying MHC class II Presentation of Immobilized Antigen by B Lymphocytes
. This allows T-B cooperation, a cellular communication that is required for B cells to develop into germinal centers (GC) and form mature high-affinity antibody producing cells and to further develop B cell memory. MHC class II antigen presentation by B
Tetrameric major histocompatibility complex (MHC) class I-peptide complexes (tetramers) are a powerful tool in the study of antigen-specific CD8+ T cell responses (1 ,2 ). Although the interaction of a monomeric MHC-peptide complex
Quantitating MHC Class I Ligand Production and Presentation Using TCR-Like Antibodies
Accurately determining the number of peptide–MHC class I complexes on the cell surface is necessary when evaluating cellular processes or pharmaceuticals that alter the antigen presentation machinery. Here I describe a quantitative flow
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