- ￥880
- Bioss
- bs-9459P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-9459P |
| 英文名称 | HAND1 Antibody Blocking Peptide |
| 中文名称 | 心脏和神经嵴衍生蛋白1封闭多肽 |
| 英文别名 | autonomic nervous system and neural crest derivatives-expressed protein 1; heart; Basic helix loop helix transcription factor HAND1; Class A basic helix-loop-helix protein 27; Extraembryonic tissues; Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1; HAND 1; HAND1; HAND-1; HAND1_HUMAN; Heart and neural crest derivatives expressed 1; Heart and neural crest derivatives expressed protein 1; Heart-and neural crest derivatives-expressed protein 1; Hxt; Thing 1; Thing1. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Developmental Biology > Lineage specification > Ectoderm Epigenetics and Nuclear Signaling > Transcription > Other factors Stem Cells > Lineage Markers > Ectoderm |
| 亚基 | Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC (By similarity). |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Heart. |
| 翻译后修饰 | Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to tranlocation into the nucleoplasm, allowing dimerization and transcription factor activity (By similarity). |
| 相似性 | Contains 1 bHLH (basic helix-loop-helix) domain. |
| 功能 | Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes.dHAND (for deciduum, heart, autonomic nervous system and neural crest derivatives; also designated HAND2) and eHAND (also designated HAND1, HXT or Thing1) are members of a subclass of basic-helix-loop-helix transcription factors that are involved in cardiac development. dHAND and eHAND are expressed in the heart after cardiac looping, and they participate in left-right cardiac asymmetry. dHAND is expressed predominantly on the right side of the looped heart tube and in the pulmonary ventricle, where it activates transcription of various genes, including Ufd1 (for ubiquitin fusion degradation) and Cdc45. In addition, dHAND is expressed in sympathetic neurons and chromafin cells throughout embryonic and fetal development and mediates neural crest development. eHAND expression is primarily observed on the left side and in the systemic ventricle, suggesting that these proteins are involved in the development of segments of the heart tube, which give rise to specific heart chambers during cardiogenesis. |
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HAND1 Antibody Blocking Peptide(bs-9459P)-500ug
￥880
