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- Bioss
- bs-20762P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-20762P |
| 英文名称 | HtrA2/Omi Antibody Blocking Peptide |
| 中文名称 | 线粒体丝氨酸蛋白酶封闭多肽 |
| 英文别名 | HtrA2 / Omi; HTRA2; OMI; High temperature requirement protein a2; HTRA 2; HtrA like serine protease; HtrA serine peptidase 2; Omi stress regulated endoprotease; PARK 13; PARK13; Protease serine 25; PRSS 25; PRSS25; Serine protease 25; Serine protease HTRA2 mitochondrial; HtrA2; HTRA2_HUMAN; mitochondrial; Omi stress-regulated endoprotease; Serine protease HTRA2; Serine proteinase OMI; Serine protease htra2 mitochondrial precursor; Serine protease omi. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cancer > Invasion/microenvironment > Apoptosis Cell Biology > Apoptosis > Mitochondrial Cell Biology > Other Antibodies > Oxidative Stress Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease > Parkin / PARK |
| 亚基 | Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce. |
| 亚细胞定位 | Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID. |
| 组织特异性 | Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid. |
| 相似性 | Belongs to the peptidase S1B family. Contains 1 PDZ (DHR) domain. |
| 功能 | Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008] |
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HtrA2/Omi Antibody Blocking Peptide(bs-20762P)-500ug
￥880
