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MARCH3 Antibody Blocking Pepti

de(bs-9337P)-500ug
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  • ¥880
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  • bs-9337P
  • 2025年10月16日
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      500ug

    产品编号bs-9337P
    英文名称MARCH3 Antibody Blocking Peptide
    中文名称膜相关环指蛋白3封闭多肽
    英文别名E3 ubiquitin-protein ligase MARCH3; FLJ20096; MARCH-III; March3; MARH3_HUMAN; Membrane associated ring finger (C3HC4) 3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING finger protein 173; RNF173.
    纯化方法HPLC
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Other E3 Ligases

    Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation

    亚基Interacts with MARCH2 and STX6 (By similarity).
    亚细胞定位Cytoplasmic vesicle membrane. Early endosome membrane.
    相似性Contains 1 RING-CH-type zinc finger.
    功能E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.

     

     

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