RanBP2 Antibody Blocking Peptide(bs-9323P)-500ug

RanBP2 Antibody Blocking Pepti

de(bs-9323P)-500ug
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  • bs-9323P
  • 2025年10月16日
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    北京博奥森生物技术有限公司
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      500ug

    产品编号bs-9323P
    英文名称RanBP2 Antibody Blocking Peptide
    中文名称RAN结合蛋白2/核孔蛋白封闭多肽
    英文别名Nuclear pore complex protein Nup358; Nucleoporin 358; Nucleoporin Nup358; NUP358; P270; RAN binding protein 2; Ran-binding protein 2; RANBP2; RBP2_HUMAN; Transformation related protein 2; TRP 1; TRP 2; TRP1; TRP2; 358 kDa nucleoporin; E3 SUMO-protein ligase RanBP2.
    纯化方法HPLC
    研究领域

    Cell Biology > Cell Cycle > Cell Division > Spindle

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Sumo

    Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing

    Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > Ubiquitin like Modifiers

    Signal Transduction > Protein Trafficking > Nuclear Import / Export

    亚基Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 but not SUMO2. Interacts with PARK2. Interacts with sumoylated RANGAP1. Interacts with CDCA8.
    亚细胞定位Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.
    相似性Contains 1 PPIase cyclophilin-type domain.
    Contains 4 RanBD1 domains.
    Contains 8 RanBP2-type zinc fingers.
    Contains 1 TPR repeat.
    功能E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The nuclear pore complex protein, Ran-binding protein 2 (Ran BP-2 or Nup358), contains four Ran-binding domains. Ran BP-2 is a large scaffold cyclophilin-related protein expressed in photoreceptor cells. Ran BP-2 localization at cytoplasmic fibrils emanating from the nuclear pore complex and interaction with the Ran-GTPase support its role in nucleocytoplasmic transport processes. In humans, the Ran BP-2 gene is partially duplicated in a gene cluster and lies in a hot spot for recombination on chromosome 2q. This genetic heterogeneity renders further significance of this genomic region in human disease due to its possible involvement in genetically linked disorders such as juvenile nephronophthisis, congenital hepatic fibrosis and chorioretinal dysplasia.

     

     

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