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- bs-20619P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-20619P |
| 英文名称 | MMP9 Antibody Blocking Peptide |
| 中文名称 | 基质金属蛋白酶-9封闭多肽 |
| 英文别名 | Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > MMPs Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MMPs Cancer > Tumor biomarkers > Enzymes > MMPs Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > MMP Cardiovascular > Atherosclerosis > Thrombosis Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > MMPs Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Atherosclerotic proteins ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cancer proteins ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Protease inhibitors ELISA kits Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP |
| 亚基 | Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. |
| 亚细胞定位 | Secreted; extracellular space; extracellular matrix. |
| 组织特异性 | Produced by normal alveolar macrophages and granulocytes. Post-translational modifications : Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. |
| 翻译后修饰 | Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. |
| 相似性 | Belongs to the peptidase M10A family. Contains 3 fibronectin type-II domains. Contains 4 hemopexin-like domains. |
| 功能 | May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-7059P is one synthetic peptide derived from human MMP-9. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]. |
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