- ￥880
- Bioss
- bs-7896P
- 2025年10月16日
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500ug
| 产品编号 | bs-7896P |
| 英文名称 | MNAT1 Antibody Blocking Peptide |
| 中文名称 | 细胞周期G1的相互作用蛋白封闭多肽 |
| 英文别名 | MNAT 1; CAP35; CDK activating kinase assembly factor MAT1; CDK7/cyclin H assembly factor; Cyclin G1 interacting protein; MAT1; Menage a trois; MNAT 1; p35; p36; RING finger protein 66; RING finger protein MAT1; RNF66; MAT1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases > Cdk Regulators Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases > Cdk Regulators Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription > TFIIH Signal Transduction > Metabolism > Amino Acids |
| 亚基 | Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes. |
| 相似性 | Contains 1 RING-type zinc finger. Contains 1 UIM (ubiquitin-interacting motif) repeat. |
| 功能 | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MNAT1 (or 'menage a trois-1') is a subunit of the CAK complex which is a multisubunit protein that includes CDK7, cyclin H, as well as MNAT1. CAK (CDK-activating kinase) phosphorylates and thus activates CDKS (Cyclin-dependent kinases) which play an essential role in cell cycle control of eukaryotic cells. |
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MNAT1 Antibody Blocking Peptide(bs-7896P)-500ug
￥880
