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- Bioss
- bs-7893P
- 2025年10月16日
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500ug
| 产品编号 | bs-7893P |
| 英文名称 | CABLES1 Antibody Blocking Peptide |
| 中文名称 | CDK5和ABL1酶底物1封闭多肽 |
| 英文别名 | CABLES; Cdk5 and Abl enzyme substrate 1; FLJ35924; HsT2563; IK3 1; Interactor with CDK3 1； CABL1_HUMAN。 |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases > Cdk Regulators |
| 亚基 | Found in a complex with p53/TP53. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7 (By similarity). |
| 亚细胞定位 | Nucleus (By similarity). Cytoplasm (By similarity). Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). |
| 组织特异性 | Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. |
| 翻译后修饰 | Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity). |
| 相似性 | Belongs to the cyclin family. |
| 功能 | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or differentiation. |
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CABLES1 Antibody Blocking Peptide(bs-7893P)-500ug
￥880
