- ￥880
- Bioss
- bs-7862P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7862P |
| 英文名称 | FAM3C Antibody Blocking Peptide |
| 中文名称 | 上皮分泌型FAM3C蛋白封闭多肽 |
| 英文别名 | Fam3c; FAM3C_HUMAN; family with sequence similarity 3, member C; GS3786; ILEI; Interleukin-like EMT inducer; Predicted osteoblast protein; Protein FAM3C. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell differentiation Immunology > Secreted Molecules > Other secreted molecules |
| 亚细胞定位 | Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells. |
| 组织特异性 | Present in most secretory epithelia (at protein level). |
| 相似性 | Belongs to the FAM3 family. |
| 功能 | May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ILEI is a 227 amino acid, ubiquitously expressed protein containing an amino-terminal signal peptide. Elevated levels of ILEI translation are observed in oncogenic, Ras-transformed mammary epithelial cells and epithelial to mesenchymal transition (Emt) as well as tumor growth and metastasis. Also, overexpression of ILEI results in loss of ZO-1, a protein involved in tight junctions, and expression of cytoplasmic E-cadherin, which has been shown to influence loss of polarity and invasiveness. Due to this evidence, it is suspected that ILEI cooperates with oncogenic Ras to cause TGF∫-independent Emt and its overexpression is correlated with the invasion, metastasis and survival in a variety of cancers. |
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FAM3C Antibody Blocking Peptide(bs-7862P)-500ug
￥880
