- ￥880
- Bioss
- bs-9240P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9240P |
| 英文名称 | RNF25 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白25封闭多肽 |
| 英文别名 | AO7; E3 ubiquitin protein ligase RNF25; E3 ubiquitin-protein ligase RNF25; RING finger protein 25; RING finger protein AO7; RNF 25; RNF25; RNF25_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase |
| 亚基 | Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity). Interacts with RELA. |
| 亚细胞定位 | Ubiquitinated. |
| 翻译后修饰 | Ubiquitinated (By similarity). |
| 相似性 | Contains 1 RING-type zinc finger. Contains 1 RWD domain. |
| 功能 | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation. |
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RNF25 Antibody Blocking Peptide(bs-9240P)-500ug
￥880
