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- Bioss
- bs-9237P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9237P |
| 英文名称 | RNF35 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白35封闭多肽 |
| 英文别名 | RING finger protein 35; Gm319; Gm35; Gm865; ring finger protein 40; Ring finger RNF35; TRIM40; Tripartite motif containing 40; Tripartite motif containing protein 40; Tripartite motif protein 40; TRI40_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase |
| 亚基 | Interacts with NEDD8. |
| 组织特异性 | Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. |
| 相似性 | Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger. |
| 功能 | May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM61 (Tripartite motif-containing protein 61), also known as RNF35 (RING finger protein 35), is a 209 amino acid protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. In mice, TRIM61 is temporarily transcribed in the early embryo, but then is permanently silenced before the blastocyst stage of development. Transcription of TRIM61 is positively regulated by nuclear factor Y (NF-Y). The gene encoding TRIM61 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. |
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RNF35 Antibody Blocking Peptide(bs-9237P)-500ug
￥880
