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- Bioss
- bs-9235P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-9235P |
| 英文名称 | CDX1 Antibody Blocking Peptide |
| 中文名称 | 尾侧型同源转录因子1封闭多肽 |
| 英文别名 | Caudal type homeo box transcription factor 1; Caudal type homeobox 1; Caudal type homeobox protein; Caudal type homeobox protein CDX1; Caudal type homeobox transcription factor 1; Caudal-type homeobox protein 1; CDX1; CDX1_HUMAN; Homeobox protein CDX 1; Homeobox protein CDX-1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Intestinal epithelium. |
| 相似性 | Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | Could play a role in the terminal differentiation of the intestine. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila ‘caudal’ gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein. |
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CDX1 Antibody Blocking Peptide(bs-9235P)-500ug
￥880
