- ￥880
- Bioss
- bs-9234P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-9234P |
| 英文名称 | CREG1 Antibody Blocking Peptide |
| 中文名称 | E1A激活基因刺激蛋白1封闭多肽 |
| 英文别名 | Cellular repressor of E1A stimulated genes 1; Cellular repressor of E1A-stimulated genes 1; CREG; CREG1_HUMAN; Protein CREG1. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cell differentiation Cancer > Oncoproteins/suppressors > Viral proteins > Adenovirus Cell Biology > Cell Cycle > Cell differentiation Epigenetics and Nuclear Signaling > Cell cycle > Cell Differentiation Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription |
| 亚基 | Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation. |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Belongs to the CREG family. |
| 功能 | May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG (cellular repressor of E1A-stimulated genes) is a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. CREG was initially isolated in a yeast two-hybrid screen due to its interaction with the TATA-binding protein, TBP. Binding sites for E2F, a key transcriptional reg-ulator of cell cycle progression, are required for repression of the adeno-virus E2 promoter by CREG, and CREG was shown to inhibit activation by E2F. CREG is broadly expressed in adult tissues and is regulated during embryonic development. CREG is a secreted glycoprotein which enhances differentiation of mouse embryonic stem cells and human NTERA-2 cells. CREG activity may contribute to the transcriptional control of cell growth and differentiation. |
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CREG1 Antibody Blocking Peptide(bs-9234P)-500ug
￥880
