- ￥880
- Bioss
- bs-20496P
- 2025年10月16日
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500ug
| 产品编号 | bs-20496P |
| 英文名称 | TUBA1A Antibody Blocking Peptide |
| 中文名称 | 微管蛋白α 1A/1B（内参）封闭多肽 |
| 英文别名 | TUBA1A + TUBA1B; Tubulin, Alpha 1b; Tubulin Alpha-Ubiquitous Chain; Alpha-Tubulin Ubiquitous; Tubulin K-Alpha-1; Tubulin, Alpha, Ubiquitous; Tubulin Alpha-1B Chain; Alpha Tubulin; Tubulin-alpha; Ubiquitous; K-ALPHA-1; Tubulin Alpha; TBA1B_HUMAN; Tubulin, Alpha 1a; TUBA3; Tubulin Alpha-3 Chain; Tubulin B-Alpha-1; LIS3; Tubulin, Alpha, Brain-Specific; Tubulin Alpha-1A Chain; Alpha-Tubulin 3, Brain-Specific; Hum-A-Tub1; Hum-A-Tub2; B-ALPHA-1; TBA1A_HUMAN; |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > Tubulin |
| 亚基 | Dimer of alpha and beta chains. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. |
| 组织特异性 | Ubiquitously expressed with highest levels in Brain, Bone, Adipocyte, and Breast |
| 翻译后修饰 | Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling. |
| 相似性 | Belongs to the tubulin family. |
| 功能 | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-0159P is one synthetic peptide derived from human Tubulin-alpha 1. Tubulin is a major cytoskeleton that has five distinct forms, designated alpha, beta, gamma, delta and epsilon tubulin. The alpha and beta tubulins form a heterodimer that polymerize into the cylindrical microtubule fibers. Both alpha and beta tubulin bind GTP. Only beta tubulin hydrolyzes GTP to GDP. This hydrolysis is a process that is linked to tubulin polymerization and microtubule formation. The alpha tubulin isomer can be modified by addition of a C-terminal tyrosine residue. This modification may influence polymerization rates. The gamma tubulin isomer is localized to centrosomes which compose the heart of the microtubule organizing center from which microtubule fibers emanate. |
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TUBA1A Antibody Blocking Peptide(bs-20496P)-500ug
￥880
