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- Bioss
- bs-9163P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9163P |
| 英文名称 | RNF17 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白17封闭多肽 |
| 英文别名 | Mmip 2; Mmip2; Ring finger protein 17; RNF 17; SPATA 23; SPATA23; Spermatogenesis associated 23; TDRD 4; TDRD4; Tudor domain containing 4. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates (By similarity). |
| 亚细胞定位 | Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). |
| 组织特异性 | Testis specific. |
| 相似性 | Contains 1 RING-type zinc finger. Contains 4 Tudor domains. |
| 功能 | Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF17 (ring finger protein 17) or tudor domain-containing protein 4, TDRD4, SPATA23, Mmip-2 or FLJ11045, is a testis-specific protein and and novel key regulator of spermiogenesis containing 1,623 amino acids. By distributing Mad proteins to the cytoplasm, RNF17 regulates the transcriptional activity of c-Myc. Although showing localization in the nucleus, RNF17 is predominantly observed in cytoplasm and is a component of a novel nuage found in male germ cells. The gene encoding RNF17 maps to human chromosome 13q12.12 and encodes one RING-type zinc finger and four tudor domains. As a result of alternative splice events, five RNF17 isoforms exisit. |
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RNF17 Antibody Blocking Peptide(bs-9163P)-500ug
￥880
