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- Bioss
- bs-9153P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-9153P |
| 英文名称 | TRIM5 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白88封闭多肽 |
| 英文别名 | TRIM5 alpha; RING finger protein 88; RNF88; TRIM5; TRIM5_HUMAN; tripartite motif protein 5; tripartite motif protein TRIM5; Tripartite motif-containing protein 5. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Ubiquitylation Immunology > Immune System Diseases > Antiviral Signaling > HIV-related |
| 亚基 | Isoform Alpha forms homotrimers, and may interact with retroviral CA protein. Isoform Delta interacts with BTBD1 and BTBD2. |
| 亚细胞定位 | Cytoplasm, P-body. |
| 翻译后修饰 | Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro). |
| 相似性 | Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. |
| 功能 | Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TRIM5a is a 493 amino acid member of the large tripartite motif protein (TRIM) family. TRIM proteins are composed of three zinc-binding domains, a RING, a B-box 2 and a coiled-coil domain, and they use homomultimerization to identify different cell compartments. Some TRIM proteins, such as TRIM5? also possess a carboxy-terminal B30.2 (SPRY) domain and localize to the cytoplasm. TRIM5?mediates innate intracellular retroviral resistance, which is dependent on its carboxy-terminal domain. The three variable regions of the B30.2 domain form loops on one side of the B30.2 core structure of TRIM5?which may form a binding surface for the virus. TRIM5?trimerization plays a major role in its affinity for the retroviral capsid, and in its ability to inhibit virus infection. The linker region between the coiled-coil and B30.2 domains of TRIM5?is required for this trimerization. TRIM5?blocks infection after the virus has entered the cell. |
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TRIM5 Antibody Blocking Peptide(bs-9153P)-500ug
￥880
