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- Bioss
- bs-9145P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9145P |
| 英文名称 | UBOX5/RNF37 Antibody Blocking Peptide |
| 中文名称 | 泛素结合酶7相互作用蛋白5封闭多肽 |
| 英文别名 | UIP5; UIP-5; UIP 5; RING finger protein 37; RNF37; U-box domain containing 5; U-box domain-containing protein 5; UBCE7IP5; ubiquitin conjugating enzyme 7 interacting protein 5; UBOX5; RNF37_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with UBE2L3; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (By similarity). Interacts with RECQL4. |
| 亚细胞定位 | Nucleus. Note=Associated with chromatin during meiosis. |
| 组织特异性 | Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). |
| 相似性 | Belongs to the UBR1 family. |
| 功能 | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The U-box domain is a modified RING finger motif that has been implicated in the ubiquitin/proteasome system. The ubiquitin-conjugating enzyme 7-interacting protein 5 (UIP5), also designated U-box domain-containing protein 5 or RING finger protein 37, contains 1 RING-type zinc finger and 1 U-box domain. UIP5 has been shown to interact with UBCH7, an enzyme that mediates selective degradation of abnormal proteins. The gene encoding UIP5 maps to chromosome 20, which houses over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception. |
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UBOX5/RNF37 Antibody Blocking Peptide(bs-9145P)-500ug
￥880
