- ￥880
- Bioss
- bs-9121P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9121P |
| 英文名称 | FBXO21 Antibody Blocking Peptide |
| 中文名称 | F-box蛋白21封闭多肽 |
| 英文别名 | F box only protein 21; F box protein 21; F-box only protein 21; FBX21; FBX21_HUMAN; Fbxo21; FLJ90233; KIAA0875; MGC26682. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > F Box E3 Ligase Epigenetics and Nuclear Signaling > Transcription > Domain Families > F-box |
| 亚基 | Directly interacts with SKP1 and CUL1 (By similarity). |
| 相似性 | Contains 1 F-box domain. |
| 功能 | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. |
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FBXO21 Antibody Blocking Peptide(bs-9121P)-500ug
￥880
