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- Bioss
- bs-9110P
- 2025年10月16日
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500ug
| 产品编号 | bs-9110P |
| 英文名称 | ATAD2 Antibody Blocking Peptide |
| 中文名称 | 三磷酸腺苷酶家族蛋白2封闭多肽 |
| 英文别名 | AAA nuclear coregulator cancer-associated protein; ANCCA; Atad2; ATAD2_HUMAN; ATPase family AAA domain containing 2; ATPase family AAA domain containing protein 2; ATPase family AAA domain-containing protein 2. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Estrogen Epigenetics and Nuclear Signaling > Bromodomains Epigenetics and Nuclear Signaling > Transcription > Bromodomain containing Signal Transduction > Metabolism > Plasma Membrane > ATPases Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones |
| 亚基 | Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro). |
| 亚细胞定位 | Nucleus |
| 组织特异性 | Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. |
| 相似性 | Belongs to the AAA ATPase family. Contains 1 bromo domain. |
| 功能 | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. |
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ATAD2 Antibody Blocking Peptide(bs-9110P)-500ug
￥880
